| Measure effect of target protein expression pre and post treatment |
Measure effect of target protein expression before and after treatment |
Validation of molecular biomarkers |
Retrospective analysis of patient cohort to identify biometric signatures associated with response |
| Quantitate disease markers pre and post treatment |
Quantitate disease markers pre and post treatment |
Retrospective analysis of responders to construct biometric profile (molecular, histological, clinical attributes). |
Prospective identification of therapeutic responders for smaller, less costly, trials with higher response rates |
| Quantitate disease and target markers as a result of dosing and time course studies |
Identify correlations between disease markers expressed in human tissue compared to animal models |
Prospective identification of therapeutic responders for smaller, less costly, trials with higher response rates |
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