Clinical Publications

Aureon has presented data in peer-reviewed journals as well as at meetings describing the application of Systems Pathology to medicine.

Clinical Publications

A Pre-treatment Systems Pathology Model Predicts the Likelihood of Disease Progression in Patients Treated with Primary Radiotherapy (25.42 KB)
Author(s); Donovan MJ, Khan F, Fernandez G, Bayer-Zubek V, Albertsen PC. 2010 American Society of Clinical Oncology (ASCO) in Chicago, IL.

Systems-based Prostate Cancer Pre-treatment Models Re-classify some High-risk Patients as Low Risk for Disease Progression and Incorporate H&E Morphometry which Reliably Discriminates Low and High Gleason Grades in the Prostate Needle Biopsy (14.59 KB)
Author(s); Donovan MJ, Khan F, Powell D, Bayer-Zubek V, Powell D, Cordon-Cardo C., 2010 American Urological Association (AUA) Annual Meeting in San Francisco, CA.

Comparison of a Novel Favorable Pathology Model with Stage (Clinical or Pathologic) or Biopsy Gleason Score for Predicting Biochemical Recurrence (14.13 KB)
Author(s); Donovan MJ, Khan F, Bayer-Zubek V, Powell D, Alter J., 2010 Society of Surgical Oncology (SSO) in St. Louis, MO.

Use of a Preoperative Systems Pathology Model to Predict the Likelihood of Favorable Pathology (FP) at Prostatectomy and Subsequent Outcomes (25.13 KB)
Author(s); Donovan MJ, Khan F, Bayer-Zubek V, Karnes RJ., 2010 American Society of Clinical Oncology Genitourinary Urology (ASCO-GU) in San Francisco, CA.

Postoperative Systems-Based Models are More Accurate than Surgical Margins and Extracapsular Extension for Predicting PSA Recurrence and Clinical Failure (10.13 KB)
Author(s); MJ Donovan, F Khan, D Powell, V Bayer-Zubek, C Cordon-Cardo, IRUS: January 2010; abstr

The Prostate Px+ Test on Prostate Biopsy Tissue Predicts for Favorable Radical Prostatectomy Pathology and has High Concordance with d’Amico Risk Group Classification (48.67 KB)
Author(s); Hyndman HE, Askin FB, Pavlovich CP. 2010 International Prostate Cancer Update (IPCU) in Vail, CO.

Prostate Biopsies from African-American Men Express Higher Levels of Aggressive Disease Biomarkers than Prostate Biopsies from Caucasian Men (67.67 KB)
Author(s); Howard Kim, Daniel M. Moreira MD, Jayakrishnan Jayachandran MD, Leah Gerber MS, Lionel L. Bañez MD, Robin Vollmer MD, Amy Lark MD, Michael J. Donovan MD, Douglas Powell, Faisal M. Khan and Stephen J. Freedland MD, Society of Urologic Oncology (SUO): December 2009; abstr

Incorporation of the Prostate Px®+ Pretreatment Score to Reclassify AUA Intermediate Risk Patients as Low or High Risk for Disease Progression and Favorable Surgical Outcome. (13.35 KB)
Author(s); Donovan MJ, Khan F, Bayer-Zubek V, Cordon-Cardo C, Society of Urologic Oncology (SUO): December 2009; abstr

Androgen Receptor Expression is Associated With Prostate Cancer Specific Survival in a Castrate Metastatic Cohort
Author(s); Donovan MJ, Osman I, Khan F, Vengrenyuk Y, Capodieci P, Koscuiszka P, Anand A, Cordon-Cardo C, Costa J, Scher H. BJU International: July 2009.

Characterization of Lymphoid Infiltrates in Prostatectomy Specimens Post Neoadjuvant Hormonal Therapy Using Quantitative Immunofluorescence and RNA FISH.
Author(s); Donovan MJ, Khan F, Powell D, Capodieci P, Gleave M, Taylor I, Gomez-Navarro J, Cordon-Cardo C., ASCO 2009 Annual Meeting.

Employing Multiplex Immunofluorescence to Quantify Her2 and Phosphorylated Her2 in Formalin-fixed, Paraffin-embedded Breast Tumor Specimens
Author(s); Donovan MJ, Puig P, Erill N, Clayton M, Hamann S, Khan F, Powell D, Costa J, Cordon-Cardo C, Baselga J. 2009 Madrid Breast Cancer Conference in Madrid, Spain. Breast Cancer Research 11:2009 (Suppl. 1).

Systems Pathology: a Paradigm Shift in the Practice of Diagnostic and Predictive Pathology
Author(s); Donovan MJ, Costa J, Cordon-Cardo C. Cancer 115(13 Suppl):3078-84 (July 1, 2009).

Personalized Prediction of Tumor Response and Cancer Progression on Prostate Needle Biopsy
Author(s); Michael J. Donovan, Faisal M. Khan, Gerardo Fernandez, Ricardo Mesa-Tejada, Marina Sapir, Valentina Bayer Zubek, Douglas Powell, Stephen Fogarasi, Yevgen Vengrenyuk, Mikhail Teverovskiy, Mark R. Segal, R. Jeffrey Karnes, Thomas A. Gaffey, Christer Busch, Michael Haggman, Peter Hlavcak, Stephen J. Freedland, Robin T. Vollmer, Peter Albertsen, Jose Costa, Carlos Cordon-Cardo, Journal of Urology: July 2009; abstr

Prediction of Disease Progression Including Durable Response to Hormonal Therapy at Diagnosis, Using the Prostate Needle Biopsy and Pretreatment Clinical Variables (17.16 KB)
Author(s); Donovan M, Khan F, Powell D, Fernandez G, Mesa-Tejada R, Sapir M, Bayer-Zubek V, Fogarasi S, Vengrenyuk Y, Teverovskiy M, Yonkers, NY; Karnesm R, Gaffey T, Rochester, MN; Busch C, Uppsala, Sweden; Freedland S, Durham, NC; Albertsen S, Farmington, CT; Costa J, New Haven, CT; Cordon-Cardo C, New York City, NY, American Urological Association Annual Meeting (2009)

Systems Pathology Approach for the Prediction of Prostate Cancer Progression after Radical Prostatectomy (858.28 KB)
Author(s); M. J. Donovan, S. Hamann, M. Clayton, F. Khan, M. Sapir, V. Bayer-Zubek, G. Fernandez, R. Mesa-Tejada, V. Reuter, P. Scardino, C. Cordon-Cardo, J Clin Oncol 26(24): 3923-3929 (2008)

A Systems Pathology Approach to Predict Prostate Cancer Progression, Post Radical Prostatectomy, at the Time of Diagnosis: Interim Results From a Multi-Center Study
Author(s); M. J. Donovan, R. Mesa-Tejada, M. Teverovskiy, F. Khan, T. Gaffey, R. J. Karnes, C. Busch, M. Haggmanm, S. Freedland, P. C. Albertsen, C. Cordon-Cardo, J Clin Oncol 26: May 20 suppl; ASCO abstr 5062 (2008)

Improved Prediction of Prostate Cancer Recurrence Through Systems Pathology (761.85 KB)
Author(s); Cordon-Cardo C, Kotsianti, A, Verbel D, Teverovskiy M, Capodieci P, Hamann S, Jeffers Y, Clayton M, Elkhettabi F, Khan F, Sapir M, Bayer V, Vengrenyuk Y, Fogarsi S, Saidi O, Reuter V, Scher H, Kattan M, Bianco F, Wheeler T, Ayala G, Scardino P, Donovan M., Journal Clinical Investigation 117:1876-1883 (2007)

Androgen Receptor Levels in Both Needle Biopsy and Prostatectomy Specimens are Associated with Overall Survival in Castration Resistant Disease
Author(s); Donovan MJ, Koscuiszka M, Aseem A, Khan F, Levy A, Capodieci P, Clayton M, Hamann S, Scher H., ASCO Genitourinary Symposium (2008)

Cyclin D-1, Interleukin-6, HER-2/neu, Transforming Growth Factor Receptor-II and Prediction of Relapse in Women with Early Stage, Hormone Receptor-Positive Breast Cancer Treated with Tamoxifen (477.03 KB)
Author(s); Muss H, Bunn J, Crocker A, Plaut K, Koh J, Heintz N, Rincon M, Weaver D, Tam D, Beatty B, Kaufman P, Donovan M, Verbel D, Weiss L. Breast J 13(4):337-45 (2007)

A Systems Pathology Model for Predicting Overall Survival in Patients with Refractory, Advanced Non-Small Cell Lung Cancer (NSCLC) Treated with Gefitinib
Author(s); Donovan M, Kotsianti A, Bayer-Zubek V, Verbel D, Clayton M, Hamann S, Capodieci P, Pang H, Cordon-Cardo C, Parums D, Holloway B., ASCO Annual Meeting (2007)

Multi-feature Prostate Cancer Diagnosis and Gleason Grading of Histological Images (1.22 MB)
Author(s); Tabesh A, Teverovskiy M, Pang H.-Y, Kumar VP, Verbel D, Kotsianti A, Saidi O., IEEE Transactions on Medical Imaging 26(10):1366-1378 (2007)

Androgen Receptor Content, as Determined by Quantitative Immunofluorescence, Plays a Significant Role in a Model Predicting Time to Clinical Progression Post Radical Prostatectomy
Author(s); Donovan M, Cordon-Cardo C, Hamann S, Kahn F, Clayton M, Teverovskiy M, Sapir M, Vengrenyuk Y, Eggener S, Scardino P., ASCO Prostate Cancer Symposium (2007)

Strategies to Quantify the Androgen Receptor in Prostate Cancer using Quantitative Immunofluorescence and Spectral Imaging
Author(s); Donovan M, Hamann S, Clayton M, Teverovskiy M, Vengrenyuk Y, Kahn F, Capodieci P, Kotsianti A, Cordon-Cardo C, ASCO Prostate Cancer Symposium (2007)

Androgen receptor (AR) Level in the Prostatectomy Specimen Predicts Time to Disease Progression Post Androgen Suppression Therapy
Author(s); Cordon-Cardo C, Donovan MJ, Khan F, Teverovskiy M, Hamann S, Eggener S, Vicars A, Scardino P., ASCO Annual Meeting (2007)

Diagnostic Sub-Classification of Non-Small Cell Lung Cancer (NSCLC) : Importance in clinical Therapeutics and Prognostication
Author(s); Puig X, Donovan MJ, Kotsianti A, Cordon-Cardo C., ASCO Annual Meeting (2005)

Technology Insight: Will Systems Pathology Replace the Pathologist? (394.2 KB)
Author(s); Saidi A, Cordon-Cardo C, Costa J., Nature Clinical Practice 4:39-45 (2006)

Further Advances in Systems Pathology Improves upon the Ability to Predict PSA Recurrence in Prostate Cancer (73.38 KB)
Author(s); Cordon-Cardo C, Kotsianti A, Donovan MJ, Capodieci P, Verbel DA, Sapir M, Teverovskiy M, Saidi O, Edelson J, Wheeler TM, Ayala G. ASCO Prostate Cancer Symposium (2005)

A Systems Pathology Approach to Predict Survival after Radical Prostatectomy (74.5 KB)
Author(s); Cordon-Cardo C, Kotsianti A, Donovan MJ, Capodieci P, Verbel DA, Sapir M, Teverovskiy M, Saidi O, Wheeler TM, Ayala G, Scardino P., American Urological Association Annual Meeting (2005)

The Future of Predictive Testing in Clinical Trials (104.26 KB)
Author(s); Donovan MJ and Cordon-Cardo C., Applied Clinical Trials (2005)

Automated Prostate Cancer Diagnosis and Gleason Grading of Tissue Microarrays (1.27 MB)
Author(s); Tabesh A, Kumar VP, Pang H, Verbel D, Kotsianti A, Teverovskiy M, Saidi O. . SPIE International Symposium on Medical Imaging Conference Proceedings, (2005)

Integration of Morphometrics with Quantitative (Multiplex) Immuno-Fluorescence to Develop Predictive Pathology Tests for Prostate Cancer Care (1.45 MB)
Author(s); Kotsianti A, Hamann S, Teverovskiy M, Verbel D, Saidi O, Cordon-Cardo C, Donovan MJ., AACR Basic, Translational, and Clinical Advances in Prostate Cancer Conference Proceedings (2004)

Advances in Systems Pathology Improves upon the Ability to Predict PSA Recurrence (73.06 KB)
Author(s); Cordon-Cardo C, Kotsianti A, Donovan MJ, Capodieci P, Verbel DA, Sapir M, Teverovskiy M, Saidi O, Edelson J, Wheeler TM, Ayala G., Prostate Cancer Foundation Scientific Retreat, (2004)

Gene Expression Profiling within Single Cells in Tissue.
Author(s); Capodieci P, Donovan MJ, Buchinsky H, Jeffers Y, Cordon-Cardo C, Gerald W, Edelson J, Shenoy SM, Singer RH. Nature Methods 2:663 (2005).

Improved Prediction of PSA Recurrence through Systems Pathology.
Author(s); Cordon-Cardo C, Kotsianti A, Donovan MJ, Capodieci P, Verbel DA, Teverovskiy M, Saidi O, Edelson J, Wheeler TM, Ayala G.; Journal of Clinical Oncology, ASCO Meeting Abstract: Jul 2004.