Clinical Publications

Aureon has presented data in peer-reviewed journals as well as at meetings describing the application of Systems Pathology to medicine.

Clinical Publications

A Systems Pathology Approach for the Prediction of Prostate Cancer Progression after Radical Prostatectomy
Author(s); M. J. Donovan, S. Hamann, M. Clayton, F. Khan, M. Sapir, V. Bayer-Zubek, G. Fernandez, R. Mesa-Tejada, V. Reuter, P. Scardino, C. Cordon-Cardo, J Clin Oncol 26(24): 3923-3929 (2008)

A Systems Pathology Approach to Predict Prostate Cancer Progression, Post Radical Prostatectomy, at the Time of Diagnosis: Interim Results From a Multi-Center Study
Author(s); M. J. Donovan, R. Mesa-Tejada, M. Teverovskiy, F. Khan, T. Gaffey, R. J. Karnes, C. Busch, M. Haggmanm, S. Freedland, P. C. Albertsen, C. Cordon-Cardo, J Clin Oncol 26: May 20 suppl; abstr 5062 (2008)

Improved Prediction of Prostate Cancer Recurrence Through Systems Pathology (761.85 KB)
Author(s); Cordon-Cardo C, Kotsianti, A, Verbel D, Teverovskiy M, Capodieci P, Hamann S, Jeffers Y, Clayton M, Elkhettabi F, Khan F, Sapir M, Bayer V, Vengrenyuk Y, Fogarsi S, Saidi O, Reuter V, Scher H, Kattan M, Bianco F, Wheeler T, Ayala G, Scardino P, Donovan M., Journal Clinical Investigation 117:1876-1883 (2007)

Androgen Receptor Levels in Both Needle Biopsy and Prostatectomy Specimens are Associated with Overall Survival in Castration Resistant Disease
Author(s); Donovan MJ, Koscuiszka M, Aseem A, Khan F, Levy A, Capodieci P, Clayton M, Hamann S, Scher H., ASCO Genitourinary Symposium (2008)

Cyclin D-1, Interleukin-6, HER-2/neu, Transforming Growth Factor Receptor-II and Prediction of Relapse in Women with Early Stage, Hormone Receptor-Positive Breast Cancer Treated with Tamoxifen
Author(s); Muss H, Bunn J, Crocker A, Plaut K, Koh J, Heintz N, Rincon M, Weaver D, Tam D, Beatty B, Kaufman P, Donovan M, Verbel D, Weiss L. Breast J 13(4):337-45 (2007)

A Systems Pathology Model for Predicting Overall Survival in Patients with Refractory, Advanced Non-Small Cell Lung Cancer (NSCLC) Treated with Gefitinib
Author(s); Donovan M, Kotsianti A, Bayer-Zubek V, Verbel D, Clayton M, Hamann S, Capodieci P, Pang H, Cordon-Cardo C, Parums D, Holloway B., ASCO Annual Meeting (2007)

Multi-feature Prostate Cancer Diagnosis and Gleason Grading of Histological Images
Author(s); Tabesh A, Teverovskiy M, Pang H.-Y, Kumar VP, Verbel D, Kotsianti A, Saidi O., IEEE Transactions on Medical Imaging 26(10):1366-1378 (2007)

Androgen Receptor Content, as Determined by Quantitative Immunofluorescence, Plays a Significant Role in a Model Predicting Time to Clinical Progression Post Radical Prostatectomy
Author(s); Donovan M, Cordon-Cardo C, Hamann S, Kahn F, Clayton M, Teverovskiy M, Sapir M, Vengrenyuk Y, Eggener S, Scardino P., ASCO Prostate Cancer Symposium (2007)

Strategies to Quantify the Androgen Receptor in Prostate Cancer using Quantitative Immunofluorescence and Spectral Imaging
Author(s); Donovan M, Hamann S, Clayton M, Teverovskiy M, Vengrenyuk Y, Kahn F, Capodieci P, Kotsianti A, Cordon-Cardo C, ASCO Prostate Cancer Symposium (2007)

Androgen receptor (AR) Level in the Prostatectomy Specimen Predicts Time to Disease Progression Post Androgen Suppression Therapy
Author(s); Cordon-Cardo C, Donovan MJ, Khan F, Teverovskiy M, Hamann S, Eggener S, Vicars A, Scardino P., ASCO Annual Meeting (2007)

Diagnostic Sub-Classification of Non-Small Cell Lung Cancer (NSCLC) : Importance in clinical Therapeutics and Prognostication
Author(s); Puig X, Donovan MJ, Kotsianti A, Cordon-Cardo C., ASCO Annual Meeting (2005)

Technology Insight: Will Systems Pathology Replace the Pathologist? (394.19 KB)
Author(s); Saidi A, Cordon-Cardo C, Costa J., Nature Clinical Practice 4:39-45 (2006)

Further Advances in Systems Pathology Improve upon the Ability to Predict PSA Recurrence in Prostate Cancer
Author(s); Cordon-Cardo C, Kotsianti A, Donovan MJ, Capodieci P, Verbel DA, Sapir M, Teverovskiy M, Saidi O, Edelson J, Wheeler TM, Ayala G. ASCO Prostate Cancer Symposium (2005)

A Systems Pathology Approach to Predict Survival after Radical Prostatectomy
Author(s); Cordon-Cardo C, Kotsianti A, Donovan MJ, Capodieci P, Verbel DA, Sapir M, Teverovskiy M, Saidi O, Wheeler TM, Ayala G, Scardino P., American Urological Association Annual Meeting (2005)

The Future of Predictive Testing in Clinical Trials (104.26 KB)
Author(s); Donovan MJ and Cordon-Cardo C., Applied Clinical Trials (2005)

Automated Prostate Cancer Diagnosis and Gleason Grading of Tissue Microarrays
Author(s); Tabesh A, Kumar VP, Pang H, Verbel D, Kotsianti A, Teverovskiy M, Saidi O. . SPIE International Symposium on Medical Imaging Conference Proceedings, (2005)

Integration of Morphometrics with Quantitative (Multiplex) Immuno-Fluorescence to Develop Predictive Pathology Tests for Prostate Cancer Care
Author(s); Kotsianti A, Hamann S, Teverovskiy M, Verbel D, Saidi O, Cordon-Cardo C, Donovan MJ., AACR Basic, Translational, and Clinical Advances in Prostate Cancer Conference Proceedings (2004)

Advances in Systems Pathology Improve upon the Ability to Predict PSA Recurrence
Author(s); Cordon-Cardo C, Kotsianti A, Donovan MJ, Capodieci P, Verbel DA, Sapir M, Teverovskiy M, Saidi O, Edelson J, Wheeler TM, Ayala G., Prostate Cancer Foundation Scientific Retreat, (2004)

Comprehensive, Personalized Prostate Cancer Disease Assessment (2.54 MB)
Aureon whitepaper describing the development and benefits of Prostate Px+, Aureon's unique prognostic test.